By Alan Peters, Deborah W. Vaughan (auth.), John E. Johnson Jr. (eds.)
Approaching any activity on getting older brings a flood of pictures which are a private repetition of what has been one of many maximum and such a lot chronic issues of mankind. Even proscribing time to the previous decade or so and coming near near basically the biomedical sciences, one nonetheless encounters a flood of knowledge during this quite younger examine sector. The ories and ideas abound as if every one researcher presents one among his personal. this could good be anticipated; getting older is a really complex sequence of crossroads concerning trails or even superhighways. each one expert has a peephole (society, physique, organ, tissue, telephone, or-especially in smooth biology-cellular organelles, macromolecules, or even molecules) and the perspectives of the crossroads are patently varied. accordingly, the num ber of observations with regards to equals the variety of self sustaining principles recommend. it really is ordinary to hunt from hugely really expert wisdom a primary comprehend ing of getting older in the course of the glossy study developments in biology that concentrate on occasions on the mobile, subcellular, macromolecular, and molecular degrees. the final word clues needs to lie there-with one severe worry: there are lots of phone forms in any physique and every phone sort is a truly complicated laptop of its personal. also, there are power repercussions in that assorted cells, tissues, or even molecules affect each other. this can be certainly a complicated scenario, and one for which we needs to search trustworthy solutions, only if we will take a step again and supply a generalized view.
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Additional resources for Aging and Cell Structure: Volume 1
Brizzee, K. , 1975a, Gross morphometric analyses and quantitative histology of the aging brain, in: Neurobiology of Aging (J. M. Ordy and K. R. ), pp. 401-423, Plenum Press, New York. Brizzee, K. , 1975b, Aging changes in relation to diseases of the nervous system, in: Neurobiology of Aging (J. M. Ordy and K. R. ), pp. 545-573, Plenum Press, New York. Brizzee, K. , and Ordy, J. , 1979, Age pigments, cell loss and hippocampal function, Mech. 9:143-162. Brizzee, K. , and Timiras, P. , 1968, A comparison of cell populations at various depth levels in cerebral cortex of young adult and aged Long-Evans rats, J.
Reichel, W. , Clark, J. , and Strehler, B. , 1968, Lipofuscin pigment accumulation as a function of age and distribution in rodent brain, J. Gerontol. 23:71-78. Rothblat, L. , and Schwartz, M. , 1979, The effect of monocular deprivation on dendritic spines in visual cortex of young and adult albino rats: Evidence for a sensitive period, Brain Res. 161:156-161. , 1955, Plexus und Meningen, in: Handbuch der ~ikroskopischen Anatomie des Menschen (W. ), Vol. IV, Part 2, Springer, Berlin. Scheibel, M.
11). A similar decrease in the cytoplasmic space occupied by ground substance has been found by Hinds and McNelly (1979) in the mitral cells of the olfactory bulb. However, in these neurons the volume fraction occupied by the RER remains constant, although in terms of the changes within individual cells the total volume of RER increases until 27 months of age, because the volumes of the mitral cells are also increasing during this period of time. The total volume of mitochondria shows a similar increase; however, after 27 months, as the neurons get smaller, both organelles decrease in amount.
Aging and Cell Structure: Volume 1 by Alan Peters, Deborah W. Vaughan (auth.), John E. Johnson Jr. (eds.)