By Qingming Luo, Lihong V. Wang, Valery V. Tuchin
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Extra resources for Advances in Biomedical Photonics and Imaging: Proceedings of the 6th International Conference on Photonics and Imaging in Biology and Medicine (Pibm 2007) Wuhan, P R China, 4-6 November 2007
Yet, it still needs a pressurized chamber which is not widely available. 24,25 Hyperoxygenation can oxygenate pre-existing hypoxic cells to make them more susceptible to PDT treatment and compensate for oxygen depletion due to PDT photochemical reactions by boosting the oxygen availability. It has been shown that above certain levels of oxygen availability there is little gain in the PDT cell killing effect. However, the gain in the technical simplicity and statistically equivalency in the biological improvement clearly indicates that normobaric hyper-oxygenation is a feasible modality to be combined with PDT than HBO.
G. 500 – 800 nm). e. g. singlet oxygen and other reactive oxygen species, ROS), and consequently induce apoptosis and/or necrosis of targeted lesion. g. 2-5 The microenvironment and physiology of solid tumors are very different from those of normal tissue. The complexity of geometry and the inhomogeneity nature of solid tumor still pose great technical challenges on the implementation of minimally invasive interstitial PDT. This article will discuss recent progress in technical development in interstitial PDT.
Photodyn. Ther. 1, 43 (2004). H. M. W. Reichert II, et al. Neurosurgery. 38, 552 (1996). A. J. Vogl, D. Fromm, et al. Cancer. 98, 1767 (2003). J. Chen, L. Keltner, J. Christophersen, et al. Cancer J. 8, 154 (2002). 23. E. M. Hahn, Photodiag. Photodyn. Ther. 1, 123 (2003). 24. Z. Huang, Q. Chen, A. Shakil, et al. Photochem. Photobiol. 78, 496 (2003). 25. Q. Chen, Z. Huang, H. Chen, J. W. Hetzel. Photochem. Photobiol. 76, 197 (2002). 26. Y. Vakrat-Haglili, L. Weiner, V. Brumfeld, et al. J. Am. Chem.
Advances in Biomedical Photonics and Imaging: Proceedings of the 6th International Conference on Photonics and Imaging in Biology and Medicine (Pibm 2007) Wuhan, P R China, 4-6 November 2007 by Qingming Luo, Lihong V. Wang, Valery V. Tuchin