By Levels, Committee On Acute Exposure Guideline
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Extra info for Acute exposure guideline levels for selected airborne chemicals : volume 14.
3 mg-min/m3), which was considered too severe to serve as a point of departure because it could result in incapacitation. 9 mg/m3] for 5 min) (Ketchum et al. S. Department of the Army 1974). Additionally, experiments with four animal species indicated that 40 mg-min/m3 was a no-effect level in monkeys, dogs, and rats (Ketchum et al. 1967); cycloplegia and mydriasis were observed in rabbits exposed at that concentration. 3 mgmin/m3, which is similar but somewhat lower than the aforementioned point of departure of 20 mg-min/m3.
The available data do not allow for assessing a minimal-effect threshold appropriate for developing AEGL-1 values. For AEGL-2 values, the point of departure was selected on the basis of preventing cognitive, behavioral, or physiologic effects. Cognitive and behavioral effects resulting from the anticholinergic activity of BZ are the most relevant effects (incapacitation) regarding human exposure to this chemical. Data for the AEGL-2 assessment are from extensive experiments using informed, human volunteers who underwent extensive screening prior to participation in the studies.
Edgewood Arsenal Special Report AD 0030. S. Department of the Army, Edgewood Arsenal, Aberdeen Proving Ground, MD. H. Snyder. 1974. Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with [3H] quinuclidinyl benzilate. Mol. Pharmacol. 10(6):861-867. 34 Acute Exposure Guideline Levels APPENDIX A DERIVATION OF AEGL VALUES FOR AGENT BZ Derivation of AEGL-1 Values Although exposures to BZ resulting in no apparent effects in animals were available, the experiments could not assess possible cognitive and behavioral effects characteristic of BZ that are relevant to humans.
Acute exposure guideline levels for selected airborne chemicals : volume 14. by Levels, Committee On Acute Exposure Guideline