Download PDF by E. Ramon-Moliner: Acetylthiocholinesterase Distribution in the Brain Stem of

By E. Ramon-Moliner

ISBN-10: 3540060367

ISBN-13: 9783540060369

ISBN-10: 3642500552

ISBN-13: 9783642500558

The earliest reports at the nearby distribution of acetylcholinesterase (AChE) in the valuable frightened process have been according to the selection of the quantity of CO liberated through homogenates of chosen components within the presence of an ester of two choline and a bicarbonate buffer. utilizing this biochemical procedure, Burgen and Chipman (1951) have been capable of identify that acetylcholinesterase isn't flippantly disbursed in the primary apprehensive process. they discovered that the cerebellum, the lateral geniculate physique, and the striatum contained a excessive focus of pain. The excessive focus of pain within the striatum can be correlated with the next expense of acetylcholine synthesis. even though, this was once now not the case for the cerebellum, the place acetylcholine synthesis was once very low. different in vitro reports were aimed toward setting up the local distribution of the opposite elements of the cholinergic approach, cholinacetylase (ChA) and acetylcholine (ACh). An both asymetrical distribution for those components has been validated in vitro (MacIntosh, 1941; Feldberg and Mann, 1946; Feldberg and V ogt, 1948; MacIntosh and Oborin, 1953; Quastel, 1962; Mitchell, 1963; Krnjevic and Phillis, 1963; Aprison et al., 1964; McLennan, 1964; Cohen, 1956). The in vitro decision of acetylcholinesterase (Koelle, 1950; Burgen and Chipman, 1951; Giacobini, 1959; Bennett et al., 1966; Fahn and Cote, 1968; Miller et al., 1969) provides the advan tage of allowing using a substrate like ACh that's a often taking place ester of choline in order that the institution of enzyme specificity is much less questionable.

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Extra resources for Acetylthiocholinesterase Distribution in the Brain Stem of the Cat

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However, in spite of such reports, this author still feels that it is justifiable to use a generic term for this territory. No outstanding cytoarchitectonic or dendroarchitectonic differences can be invoked to differentiate the caudal portions of the reticular formation from the rostral ones (Ramon-Moliner and Nauta, 1966; RamonMoliner, 1967). On the other hand, it appears desirable to comply with present nomenclature trends and reserve the term, tegmentum, for the pontomesencephalic regions of the reticular formation while retaining the term, reticular, for the most caudal portions, within the medulla.

It is interesting that, caudal to this center, the midline region of the pons (Figs. 2VI, 2 VII, and 2VIII) does not display any outstanding features. Thus, the nucleus raphe magnus described by Taber cannot be identified at all in AThChE material. 3* 36 E. Ramon-Moliner: The nucleus tegmentosus centralis superioris (CS in Figs. 3 XII through 5XVII) is a sagittally flattened agglomeration of cells which continues rostrally the centralis inferioris. It extends as far as the caudal portion of the decussation of the brachia conjunctiva.

In this respect, it is interesting that the family of organophosphorous compounds includes anticholinesterase agents, as well as demyelinating ones (Barnes and Denz, 1953). Furthermore, acetylcholine itself could be involved in activities other than those implicated in nervous transmission. The experiments of Hokin and Hokin (1956) showed that the turnover of certain phospholipid compounds is increased when acetylcholine is applied either to brain tissue, submandibular and parotid salivary glands, or pancreas.

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Acetylthiocholinesterase Distribution in the Brain Stem of the Cat by E. Ramon-Moliner


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