By Prof. Dr. Michael L. G. Gardner, Prof. Dr. Klaus-Jürgen Steffens (auth.)
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One must first consider the amount originally administered (10 mg in most cases). Using trypsin as an example, 50% of the administered 10 mg was absorbed within 60 h, leaving a residual amount of 5 mg and indicating that 5 mg had been absorbed. 5 mg was present in a macromolecular state. The Quantitative Absorption of Orally Administered Proteins 33 [mg/%] 80 60 40 20 0 Amylase Trypsin Chymotrypsin Papain Pancreatin • ~ III ~ ~ Appl. 43 Fig. 4. Quantitative analysis of enzyme absorption from the gut Since the amount of enzymes absorbed varies from enzyme to enzyme, one must then consider whether the absorbed enzyme can reach the site at which it· is intended to be active, namely at the wound.
First the proteins or enzymes are radiolabeled so that the radioactivity can be measured. The second step is chromatographic examination of the molecular weight of these radioactively labeled substances following absorption. The third step involves immunological testing methods to identify the protein administered to the organism as a foreign protein. This is performed with the aid of antisera. This set of tests makes it possible to calculate the absorption rates of these proteins and enzymes [10, 13].
Pharm Res 6S:31 39. 26) activity in the colon and its role in the degradation of thyrotropin releasing hormone in the albino rabbit. Pharm Res 6S: 31 40. Buur A, Yamamoto A, Lee VHL (1990) Penetration of 5-fluorouracil and prodrugs across the intestine of the albino rabbit: evidence for shift in absorption site from the upper to the lower region of the gastrointestinal tract by prodrugs. J Contr ReI 14:43-51 41. Narawane M, Podder SK, Bundgaard H, Lee VHL (1993) Segmental differences in drug permeability, esterase activity and ketone reductase activity in the albino rabbit intestine.
Absorption of Orally Administered Enzymes by Prof. Dr. Michael L. G. Gardner, Prof. Dr. Klaus-Jürgen Steffens (auth.)